Proteoform Thursday: Jeffrey Huang presents “A Catenin Phospho-Code for Adherens Junction Organization”
March 26, 2026 11:00 AM in Eastern Time (US and Canada)
Proteoforms, defined by the precise primary structure of proteins, are becoming a central currency in modern proteomics because they more directly link to cellular functions and disease phenotypes. Recent advances in individual ion mass spectrometry/direct 
mass technology (I2MS/DMT) allow characterization of proteoforms above 100 kDa, expanding access to previously intractable protein complexes. Using I2MS, mechano-sensitive phosphorylation patterns in β- and α-catenins at adherens junctions can be resolved, supporting a model of a “catenin phospho-code” that links proteoform-level structural variation to cell–cell adhesion dynamics.