February 8, 2018 — The Consortium for Top-Down Proteomics has published the first standard notation, called ProForma, for writing the sequences of fully characterized proteoforms. ProForma allows researchers to readily communicate and share proteoform information, and the notation is the unambiguous, human readable, and can easily be parsed and written by bioinformatic tools. This should help simplify storage and comparisons, and increase the utilization of proteoform information, leading to new discoveries.
- ProForma: a Standard Proteoform Notation
Richard D. LeDuc, Veit Schwämmle, Michael R. Shortreed, Anthony J. Cesnik, Stefan K. Solntsev, Jared B. Shaw, Maria J. Martin, Juan A. Vizcaíno, Emanuele Alpi, Paul Danis, Neil L. Kelleher, Lloyd M. Smith, Ying Ge, Jeffrey N. Agar, Julia Chamot-Rooke, Joseph Loo, Ljiljana Paša-Tolić, and Yury O. Tsybin, Journal of Proteome Research, published online February 5, 2018.
Proteoform Thursday – April 22 – – – Prof. Nick Young presents Quantitative Proteoform Biology
Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry
Top-Down Proteomics at ASMS2020
An exciting ASMS meeting is upon us and we have compiled a list of all the great presentations and workshops at the ASMS Reboot 2020.
Don’t miss these LIVE events
Click here to download the TDP at ASMS2020.
Consortium for Top-Down Proteomics Launches Native Top-Down Initiative
A New Classification System for Proteoform Identifications
Best practices and benchmarks for intact protein analysis for top-down mass spectrometry
Announcement: 1st European Top-Down Proteomics Symposium, Feb. 12-14, 2019, Paris, France
Free Download > Proteoforms as the next proteomics currency
Consortium for Top-Down Proteomics Publishes Standard Notation for Proteoforms
February 8, 2018 — The Consortium for Top-Down Proteomics has published the first standard notation, called ProForma, for writing the sequences of fully characterized proteoforms. ProForma allows researchers to readily communicate and share proteoform information, and the notation is the unambiguous, human readable, and can easily be parsed and written by bioinformatic tools. This should help simplify storage and comparisons, and increase the utilization of proteoform information, leading to new discoveries.
Richard D. LeDuc, Veit Schwämmle, Michael R. Shortreed, Anthony J. Cesnik, Stefan K. Solntsev, Jared B. Shaw, Maria J. Martin, Juan A. Vizcaíno, Emanuele Alpi, Paul Danis, Neil L. Kelleher, Lloyd M. Smith, Ying Ge, Jeffrey N. Agar, Julia Chamot-Rooke, Joseph Loo, Ljiljana Paša-Tolić, and Yury O. Tsybin, Journal of Proteome Research, published online February 5, 2018.
Why Should We Weigh Every Protein in the Human Body?
This interview with Neil Kelleher, Consortium President, explains the importance of Top-Down Proteomics for understanding biology and accelerating drug discovery efforts.