February 8, 2018 — The Consortium for Top-Down Proteomics has published the first standard notation, called ProForma, for writing the sequences of fully characterized proteoforms. ProForma allows researchers to readily communicate and share proteoform information, and the notation is the unambiguous, human readable, and can easily be parsed and written by bioinformatic tools. This should help simplify storage and comparisons, and increase the utilization of proteoform information, leading to new discoveries.
- ProForma: a Standard Proteoform Notation
Richard D. LeDuc, Veit Schwämmle, Michael R. Shortreed, Anthony J. Cesnik, Stefan K. Solntsev, Jared B. Shaw, Maria J. Martin, Juan A. Vizcaíno, Emanuele Alpi, Paul Danis, Neil L. Kelleher, Lloyd M. Smith, Ying Ge, Jeffrey N. Agar, Julia Chamot-Rooke, Joseph Loo, Ljiljana Paša-Tolić, and Yury O. Tsybin, Journal of Proteome Research, published online February 5, 2018.
This interview with Neil Kelleher, Consortium President, explains the importance of Top-Down Proteomics for understanding biology and accelerating drug discovery efforts.
Preliminary results from 25-laboratory study demonstrate the capabilities of top-down mass spectrometry for detailing monoclonal antibody structure and modifications. The presentation is Monday, June 5 at the Top-Down Proteomics Workshop at the ASMS Conference in Indianapolis, IN
CAMBRIDGE, MA–(Marketwired – May 31, 2017) – The Consortium for Top-Down Proteomics will present the preliminary results from their inter-laboratory study for characterizing monoclonal antibodies (mAbs) by top-down mass spectrometry techniques on June 5, 2017 at the upcoming American Society for Mass Spectrometry Annual Conference. With the continuing growth in the development and adoption of mAbs for a wide range of therapeutic uses, there is increasing demand for higher quality characterization of these complex species. This study is assessing the state of the art for providing critical information on these important materials. Read more
Twenty-five laboratory study to illustrate the capabilities of top-down mass spectrometry in detailing monoclonal antibody structure and modifications
CAMBRIDGE, MA–(Marketwired – February 28, 2017) – The Consortium for Top Down Proteomics today announced the launch of their inter-laboratory study for characterizing monoclonal antibodies (mAbs) by top-down mass spectrometry techniques. With the continuing growth in the development and adoption of mAbs for a wide range of therapeutic uses, there is increasing demand for higher quality characterization of these complex species.