ANNOUNCING

THE 3rd INTERNATIONAL TOP-DOWN PROTEOMICS SYMPOSIUM
August 26-28, 2025
University of Hamburg, Germany
Education
Community
Innovative Research
Accelerating the comprehensive analysis of all human proteoforms
Speeding developments in diagnostics, therapeutics, environment, and energy

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The Human Proteoform Project
An ambitious initiative to generate a definitive reference set of the proteoforms produced from the genome, providing the bridge from genotype to phenotype

Read the Paper

Proteoform Thursday – December 12: Tarick El-Baba presents “Isolation of Metabotropic Glutamate Receptors from Human Brain Uncovers Remodeling in Depression”

Proteoform Thursday – October 17: Oliver Hale presents “Enabling Molecular Pathology of Intact Proteoform Complexes in Tissue by Mass Spectrometry”

Proteoform Thursday – September 26: Vendor Showcase presents the latest tech and apps

Proteoform Thursday – August 29: Novera Alam presents “Internal fragment disambiguation and visualization methods improve the depth of top-down mass spectrometry analysis”

Proteoform Thursday July 25: Fabio Gomes presents “Native Top-Down Characterization of Proteoforms and their Complexoforms in Breast Cancer Cells”

Top-Down Proteomics Workshop at ASMS2024

Native Top-Down Initiative Publishes Results of Community Study

Proteoform Thursday April 25: Benqian Wei presents “Internal Fragments in Top-Down and Middle-Down Mass Spectrometry: From Fundamentals to Applications”

Proteoform Thursday: March 21 – Jake Melby presents “Novel Strategies to Address the Challenge of Sensitivity in Top-down Proteomics”

Thank you to our Consortium Major Sponsors

Thank you to our Consortium Supporters

Discover Proteoforms

Characterize Antibodies.

Elucidate Native States.

Image Tissues.

Welcome to the Top-Down Community

A non-profit organization with members from academic institutions, corporations, and government agencies.

With the Mission to promote collaboration, education, and innovative research in the fields of top-down mass spectrometry

Get involved with our initiatives

Become involved in one of our initiatives aimed at furthering the field of top-down MS.

Please contact us to see how you can participate in our studies and projects.

Please contact us

Monoclonal Antibody Pilot Project

Protein Separation Project

Proteoform Nomenclature Standard

CE-MS Initiative

Native Top-Down Project

The Human Proteoform Atlas Initiative