• ANNOUNCING

    THE 3rd INTERNATIONAL TOP-DOWN PROTEOMICS SYMPOSIUM

    August 26-28, 2025
    University of Hamburg, Germany

    DETAILS COMING SOON

  • Education
    Community
    Innovative Research

    Accelerating the comprehensive analysis of all human proteoforms
    Speeding developments in diagnostics, therapeutics, environment, and energy

    JOIN HERE

  • The Human Proteoform Project

    An ambitious initiative to generate a definitive reference set of the proteoforms produced from the genome, providing the bridge from genotype to phenotype

    Read the Paper
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Proteoform Thursday – October 17: Oliver Hale presents “Enabling Molecular Pathology of Intact Proteoform Complexes in Tissue by Mass Spectrometry”

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Proteoform Thursday – August 29: Novera Alam presents “Internal fragment disambiguation and visualization methods improve the depth of top-down mass spectrometry analysis”

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Proteoform Thursday July 25: Fabio Gomes presents “Native Top-Down Characterization of Proteoforms and their Complexoforms in Breast Cancer Cells”

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Top-Down Proteomics Workshop at ASMS2024

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Proteoform Thursday April 25: Benqian Wei presents “Internal Fragments in Top-Down and Middle-Down Mass Spectrometry: From Fundamentals to Applications”

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Proteoform Thursday: March 21 – Jake Melby presents “Novel Strategies to Address the Challenge of Sensitivity in Top-down Proteomics”

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Proteoform Thursday: Feb. 29 – James Fulcher presents “How TopPICR can enhance YOUR quantitative top-down proteomic analyses”

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Thank you to our Consortium Major Sponsors

Thank you to our Consortium Supporters

Welcome to the Top-Down Community

A non-profit organization with members from academic institutions, corporations, and government agencies.

With the Mission to promote collaboration, education, and innovative research in the fields of top-down mass spectrometry

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Get involved with our initiatives

Become involved in one of our initiatives aimed at furthering the field of top-down MS.

Please contact us to see  how you can participate in our studies and projects.

Please contact us

Monoclonal Antibody Pilot Project

Protein Separation Project

Proteoform Nomenclature Standard

CE-MS Initiative

Native Top-Down Project

The Human Proteoform Atlas Initiative